What is the clinical evidence from this study?

Study design: Other. Population: Hypertension. Intervention: Quinapril vs. Enalapril (1 mg/kg). Primary outcome: Plasma and tissue angiotensin-converting enzyme (ACE) activities.

What question did this study set out to answer?

To evaluate the effects of single and repeated doses of quinapril on angiotensin-converting enzyme (ACE) activity in spontaneously hypertensive rats.

January 1, 1992Journal of Cardiovascular Pharmacology

Prolonged Inhibition of Local Angiotensin-Converting Enzyme After Single or Repeated Treatment with Quinapril in Spontaneously Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Key result

Quinapril produced more potent and prolonged inhibition of plasma, aorta, and cardiac ACE activities compared to enalapril in spontaneously hypertensive rats.

Why the study?

Does quinapril improve tissue ACE inhibition compared to enalapril in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR)

Comparison

Quinapril 1 mg/kg oral or intravenous vs Enalapril 1 mg/kg

Design

Preclinical

Follow-up

2 weeks

Authors

TNTohru NakajimaHaibara General Hospital TYTsuneyo YamadaTeikyo Heisei University MSMichihide SetoguchiKyoto Pharmaceutical Industries (Japan)

Discussion

Member takes

Implication

Quinapril may offer greater tissue ACE inhibition in hypertensive rats; leaves open clinical relevance and requires human trials before practice change.

Key Points

To evaluate the effects of single and repeated doses of quinapril on angiotensin-converting enzyme (ACE) activity in spontaneously hypertensive rats.
Single and repeated oral treatment with quinapril (1 mg/kg) and enalapril (1 mg/kg) in spontaneously hypertensive rats.
Measured plasma and tissue ACE activities post-treatment.
Observed treatment effects over a period of 2 weeks.
Single treatment with quinapril resulted in marked ACE inhibition in aorta, lung, and plasma compared to enalapril.
ACE inhibition in plasma and aorta was more potent with quinapril than enalapril.
Repeated quinapril treatment for 2 weeks sustained prolonged ACE inhibition in the aorta, indicating effective tissue penetration.

Structured PICO

Does quinapril improve tissue ACE inhibition compared to enalapril in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats treated with quinapril or enalapril to assess ACE inhibition.

Intervention

Quinapril 1 mg/kg oral (single or repeated for 2 weeks) or intravenous

Comparator

Enalapril 1 mg/kg

Outcome

Plasma and tissue (aorta, lung, cardiac) angiotensin-converting enzyme (ACE) activitiessurrogate

Quinapril demonstrates potent and prolonged tissue ACE inhibition, particularly in cardiac and aortic tissues, compared to enalapril in a hypertensive rat model.

Cite This Study

Nakajima et al. (1992) studied Hypertension. Quinapril vs. Enalapril (1 mg/kg) was evaluated on Plasma and tissue angiotensin-converting enzyme (ACE) activities. Quinapril produced more potent and prolonged inhibition of plasma, aorta, and cardiac ACE activities compared to enalapril in spontaneously hypertensive rats.

synapsesocial.com/papers/6a22ba4b98d141f28c14cdcd https://doi.org/10.1097/00005344-199201000-00014

View Full Paper

Ask AI

Bookmark

January 1, 1992Journal of Cardiovascular Pharmacology

Prolonged Inhibition of Local Angiotensin-Converting Enzyme After Single or Repeated Treatment with Quinapril in Spontaneously Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Key result

Quinapril produced more potent and prolonged inhibition of plasma, aorta, and cardiac ACE activities compared to enalapril in spontaneously hypertensive rats.

Why the study?

Does quinapril improve tissue ACE inhibition compared to enalapril in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR)

Comparison

Quinapril 1 mg/kg oral or intravenous vs Enalapril 1 mg/kg

Design

Preclinical

Follow-up

2 weeks

Authors

TNTohru NakajimaHaibara General Hospital TYTsuneyo YamadaTeikyo Heisei University MSMichihide SetoguchiKyoto Pharmaceutical Industries (Japan)

Discussion

Member takes

Implication

Quinapril may offer greater tissue ACE inhibition in hypertensive rats; leaves open clinical relevance and requires human trials before practice change.

Key Points

To evaluate the effects of single and repeated doses of quinapril on angiotensin-converting enzyme (ACE) activity in spontaneously hypertensive rats.
Single and repeated oral treatment with quinapril (1 mg/kg) and enalapril (1 mg/kg) in spontaneously hypertensive rats.
Measured plasma and tissue ACE activities post-treatment.
Observed treatment effects over a period of 2 weeks.
Single treatment with quinapril resulted in marked ACE inhibition in aorta, lung, and plasma compared to enalapril.
ACE inhibition in plasma and aorta was more potent with quinapril than enalapril.
Repeated quinapril treatment for 2 weeks sustained prolonged ACE inhibition in the aorta, indicating effective tissue penetration.

Structured PICO

Does quinapril improve tissue ACE inhibition compared to enalapril in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats treated with quinapril or enalapril to assess ACE inhibition.

Intervention

Quinapril 1 mg/kg oral (single or repeated for 2 weeks) or intravenous

Comparator

Enalapril 1 mg/kg

Outcome

Plasma and tissue (aorta, lung, cardiac) angiotensin-converting enzyme (ACE) activitiessurrogate

Quinapril demonstrates potent and prolonged tissue ACE inhibition, particularly in cardiac and aortic tissues, compared to enalapril in a hypertensive rat model.

Cite This Study

synapsesocial.com/papers/6a22ba4b98d141f28c14cdcd https://doi.org/10.1097/00005344-199201000-00014

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark