April 1, 1989Clinical and Experimental Pharmacology and Physiology

Angiotensin Converting Enzyme in the Rat Heart: Studies of Its Inhibition in Vitro and Ex Vivo

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Population

Rat heart and lung homogenates (in vitro) and rats (ex vivo)

Design

Preclinical

Authors

BFBruno FabrisOspedale di Cattinara BJBruce JacksonGlan Clwyd Hospital RCRose CubelaThe University of Melbourne

Discussion

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Implication

Higher atrial ACE affinity in rats lacks in vivo effect; leaves open relevance to human ACE inhibitor responses.

Structured PICO

Population

Rat heart and lung homogenates (in vitro) and rats (ex vivo)

Intervention

Six ACE-inhibitors (CI906, CGS14831, S9780, 351A, MK521, SQ27519) in vitro; Quinapril (CI928) 0.3 mg/kg orally ex vivo

Outcome

Equilibrium association constant (Ka) and specific binding of [125I]-351A to ACEsurrogate

ACE inhibitors demonstrate higher binding affinity in rat atria compared to lung or ventricles in vitro, though this regional difference does not affect the degree or time course of in vivo inhibition.

Cite This Study

Fabris et al. (1989) studied this question.

synapsesocial.com/papers/6a701dd0febe604dd708e91d https://doi.org/10.1111/j.1440-1681.1989.tb01563.x

View Full Paper

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Angiotensin Converting Enzyme in the Rat Heart: Studies of Its Inhibition in Vitro and Ex Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin Converting Enzyme in the Rat Heart: Studies of Its Inhibition in Vitro and Ex Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider