Angiotensin Converting Enzyme (ACE), Characterization by 125I-MK351A Binding Studies of Plasma and Tissue ACE During Variation of Salt Status in the Rat

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Structured PICO

Population

Sprague Dawley rats (n=24 per group)

Intervention

Variation of sodium intake (low salt, normal salt, high salt) and high salt + DOCA treatment

Comparator

Normal salt intake

Outcome

MK351A binding sites/mg protein and equilibrium dissociation constant (KD) in plasma and tissues (lung, aorta, brain, epididymis, kidney)surrogate

Variation in dietary sodium intake does not significantly alter ACE binding site density or affinity in rat plasma and tissues.

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Rat ACE binding unaffected by sodium; leaves open human relevance and clinical translation.

Jackson et al. (1986) studied this question.

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