Angiotensin-converting enzyme labeled with [3H]captopril. Tissue localizations and changes in different models of hypertension in the rat.
Why the study?
How does tissue angiotensin-converting enzyme (ACE) localization and quantity vary across different rat models of hypertension?
Structured PICO
How does tissue angiotensin-converting enzyme (ACE) localization and quantity vary across different rat models of hypertension?
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Population
Rat models of hypertension (two-kidney, one-clip [2K-1C]; one-kidney, one-clip [1K-1C]; desoxycorticosterone acetate [DOCA]-salt) and normotensive controls
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Intervention
In vitro autoradiography with [3H]captopril
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Comparator
Normotensive control group
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Outcome
Tissue localization and quantitation of angiotensin-converting enzyme (ACE)surrogate
Tissue ACE levels exhibit differential regulation in various models of hypertension, correlating either positively or negatively with plasma renin activity depending on the specific tissue.
Authors
Discussion
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Implication
Tissue ACE patterns in rat hypertension models leave open translation to human disease; hypothesis-generating for tissue-specific renin-angiotensin targeting.
Cite This Study
Wilson et al. (1987) studied this question.