Key result
Intracoronary enalaprilat improved the time constant of isovolumic relaxation from 56 to 49 milliseconds (P<0.01) in patients with severe hypertensive left ventricular hypertrophy.
Why the study?
Does intracoronary enalaprilat improve diastolic function in patients with hypertensive left ventricular hypertrophy?
Does intracoronary enalaprilat improve diastolic function in patients with hypertensive left ventricular hypertrophy?
Absolute Event Rate: 49% vs 56%
p-value: p=<.01
Acute intracoronary ACE inhibition improves active myocardial relaxation in patients with severe hypertensive LVH, suggesting a local role for the renin-angiotensin system in diastolic dysfunction.
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Should not change practice in hypertensive LVH; supports local renin-angiotensin role in diastolic dysfunction.
Haber et al. (1994) studied Hypertensive left ventricular hypertrophy (n=25). Intracoronary enalaprilat vs. Baseline and low-dose/non-severe LVH groups was evaluated on Time constant of isovolumic relaxation (TauL) (p=<.01). Intracoronary enalaprilat improved the time constant of isovolumic relaxation from 56 to 49 milliseconds (P<0.01) in patients with severe hypertensive left ventricular hypertrophy.
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