May 1, 1992Circulation ResearchOpen Access

Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme.

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Why the study?

Does enalaprilat improve systolic and diastolic function during low-flow ischemia and reperfusion in hypertrophied and nonhypertrophied rat hearts?

Population

Isolated, red blood cell-perfused isovolumic nonhypertrophied and hypertrophied rat hearts

Comparison

Enalaprilat (2.5 x 10 M final concentration)… vs Untreated nonhypertrophied and hypertrophied rat…

Design

Preclinical

Follow-up

80 minutes

Authors

FEFranz R. EberliInterventional Cardiology CACarl S. ApsteinHeart Failure / Cardiomyopathy SNSoeun NgoyBrigham and Women's Hospital

Discussion

Member takes

Implication

Hypothesis-generating for ACE inhibition in hypertrophied hearts during ischemia; human trials needed before clinical consideration.

Structured PICO

Does enalaprilat improve systolic and diastolic function during low-flow ischemia and reperfusion in hypertrophied and nonhypertrophied rat hearts?

Population

Isolated, red blood cell-perfused isovolumic nonhypertrophied and hypertrophied rat hearts (pressure-overload hypertrophy in response to aortic banding)

Intervention

Enalaprilat (2.5 x 10(-7) M final concentration) infusion during 20 minutes of baseline perfusion, 30 minutes of low-flow ischemia, and 30 minutes of reperfusion

Comparator

Untreated (no drug) nonhypertrophied and hypertrophied rat hearts

Outcome

Systolic and diastolic function (left ventricular developed pressure and left ventricular end-diastolic pressure) during ischemia and reperfusionsurrogate

Inhibition of cardiac angiotensin converting enzyme with enalaprilat attenuates ischemic diastolic dysfunction in pressure-overload hypertrophied rat hearts.

Cite This Study

Eberli et al. (1992) studied this question.

synapsesocial.com/papers/6a10693b28c2d29469fe74f9 https://doi.org/10.1161/01.res.70.5.931

Topics

Hypertrophic cardiomyopathy

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Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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