Why the study?
Do enalaprilat and L-158,809 improve left ventricular diastolic function in a canine model of hypertensive left ventricular hypertrophy?
Population
36 dogs: 16 normal control dogs and 20 dogs with perinephritic hypertension and left ventricular hypertrophy.
Comparison
Intravenous injection of enalaprilat or L-158,809. vs Baseline measurements and normal control dogs.
Design
Preclinical
Follow-up
Acute (before and after intravenous injection)
Authors
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Acute ACEi/ARB effects on LV stiffness in canine hypertensive LVH are hypothesis-generating; leaves open clinical translation.
Do enalaprilat and L-158,809 improve left ventricular diastolic function in a canine model of hypertensive left ventricular hypertrophy?
ACE inhibitors and angiotensin II receptor blockers acutely improve left ventricular diastolic stiffness in a canine model of hypertensive LVH, independent of myocardial perfusion changes.
Hayashida et al. (1997) studied this question.
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