Why the study?
Does enalaprilat or E-3174 improve aortic viscoelasticity in normotensive and renovascular hypertensive dogs?
Population
16 conscious dogs (8 normotensive and 8 renovascular hypertensive)
Comparison
Angiotensin I converting enzyme inhibition or… vs Pretreatment conditions
Design
Preclinical
Authors
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Findings in dogs warrant no change in human practice; extends preclinical evidence for ACE inhibitor effects on arterial viscoelasticity.
Does enalaprilat or E-3174 improve aortic viscoelasticity in normotensive and renovascular hypertensive dogs?
ACE inhibition modifies arterial viscoelastic parameters in normotensive dogs via angiotensin-independent mechanisms, contributing to the buffering function of large arteries.
Barra et al. (1997) studied this question.
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