February 3, 2003CirculationOpen Access

Angiotensin-Converting Enzyme Inhibition Increases Human Vascular Tissue-Type Plasminogen Activator Release Through Endogenous Bradykinin

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Why the study?

Does ACE inhibition increase endothelial t-PA release through endogenous bradykinin in smokers?

Structured PICO

Does ACE inhibition increase endothelial t-PA release through endogenous bradykinin in smokers?

Population

24 smokers

Intervention

Intra-arterial enalaprilat (5 micro g/min) before and during intra-arterial infusion of bradykinin (25 to 400 ng/min) and methacholine (3.2 to 12.8 microg/min), pretreated with bradykinin receptor antagonist HOE 140 (100 microg/kg intravenously)

Comparator

Intra-arterial enalaprilat with vehicle pretreatment

Outcome

Forearm blood flow (FBF) and net tissue-type plasminogen activator (t-PA) releasesurrogate

ACE inhibition increases constitutive endothelial t-PA release through endogenous bradykinin, providing a mechanistic explanation for its vascular protective effects.

Discussion

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Implication

Supports bradykinin-mediated t-PA release as ACE inhibitor mechanism; hypothesis-generating for vascular protection in smokers.

Cite This Study

Pretorius et al. (2003) studied this question.

synapsesocial.com/papers/6a70d73afe4101aa97e056ca https://doi.org/10.1161/01.cir.0000046268.59922.a4

View Full Paper

Ask AI

Bookmark

Angiotensin-Converting Enzyme Inhibition Increases Human Vascular Tissue-Type Plasminogen Activator Release Through Endogenous Bradykinin

Structured PICO

Discussion

Implication

Cite This Study

Angiotensin-Converting Enzyme Inhibition Increases Human Vascular Tissue-Type Plasminogen Activator Release Through Endogenous Bradykinin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider