September 1, 1997Clinical Pharmacology & TherapeuticsOpen Access

Endogenous angiotensin II does not contribute to sympathetic venoconstriction in dorsal hand veins of healthy humans

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Why the study?

Does losartan alter sympathetically mediated venoconstriction in healthy humans?

Structured PICO

Does losartan alter sympathetically mediated venoconstriction in healthy humans?

Population

8 healthy male volunteers

Intervention

Local intravenous administration of losartan (30 microg/min) during local infusions of angiotensin II (4 to 64 ng/min) and norepinephrine (1 to 128 ng/min) or sympathetic venoconstriction produced by a single deep breath

Comparator

Saline placebo

Outcome

Venoconstriction responses of dorsal hand veinssurrogate

Discussion

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Implication

Losartan does not blunt sympathetically mediated venoconstriction in healthy humans; confirms basal endogenous angiotensin II exerts no influence.

Cite This Study

Masumori et al. (1997) studied this question.

synapsesocial.com/papers/6a880f434c82be800eeb3f15 https://doi.org/10.1016/s0009-9236(97)90036-9

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Implication

Losartan does not blunt sympathetically mediated venoconstriction in healthy humans; confirms basal endogenous angiotensin II exerts no influence.

Endogenous angiotensin II does not contribute to sympathetic venoconstriction in dorsal hand veins of healthy humans

Structured PICO

Discussion

Implication

Cite This Study

Endogenous angiotensin II does not contribute to sympathetic venoconstriction in dorsal hand veins of healthy humans

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider