Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man
Why the study?
Does local intra-arterial losartan alter basal peripheral vascular tone in healthy humans under sodium replete and deplete conditions?
Population
Healthy humans
Comparison
Local intra-arterial administration of losartan vs Baseline and responses to exogenous angiotensin…
Follow-up
Acute
Authors
Discussion
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Member takes
Implication
Endogenous Ang II maintains basal tone only during sodium depletion; hypothesis-generating for volume-dependent RAS effects and should not yet change practice.
Structured PICO
Does local intra-arterial losartan alter basal peripheral vascular tone in healthy humans under sodium replete and deplete conditions?
P
Population
Healthy humans
I
Intervention
Local intra-arterial administration of losartan (30 and 300 micrograms/min)
C
Comparator
Baseline (sodium replete state) and responses to exogenous angiotensin I, angiotensin II, bradykinin, and noradrenaline
O
Outcome
Forearm blood flow and forearm vascular resistancesurrogate
Endogenous angiotensin II does not maintain basal peripheral vascular tone in healthy humans unless the renin-angiotensin system is activated, such as during sodium depletion.
Cite This Study
David E. Newby (1997) studied this question.