Key result
Angiotensin II infusion at 1 pmol/min significantly augmented sympathetically induced venoconstriction caused by a deep breath compared to control veins (P<0.01).
Why the study?
Does low-dose angiotensin II infusion augment sympathetically induced venoconstriction in normal volunteers?
Does low-dose angiotensin II infusion augment sympathetically induced venoconstriction in normal volunteers?
p-value: p=<0.01
Low-dose angiotensin II augments sympathetically induced venous tone via a presynaptic mechanism, providing a physiological basis for the venodilating properties of ACE inhibitors.
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Suggests mechanism for ACE inhibitor venodilation; hypothesis-generating and leaves open clinical relevance.
Benjamin et al. (1988) studied Normal volunteers (n=14). Angiotensin II (ANG II) vs. Control (adjacent hand vein) was evaluated on Constriction caused by a single deep breath (p=<0.01). Angiotensin II infusion at 1 pmol/min significantly augmented sympathetically induced venoconstriction caused by a deep breath compared to control veins (P<0.01).
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