October 1, 1998Journal of Cardiovascular Pharmacology
Inhibition of Angiotensin II-Induced Contraction by Losartan in Human Coronary Arteries
Key result
Losartan blunts Angiotensin II-induced contraction in isolated human coronary arteries.
- P=0.001
Why the study?
Does losartan inhibit angiotensin II-induced contraction in isolated human coronary arteries?
Population
Isolated human coronary artery ring segments
Comparison
Losartan (10-100 nM) incubated with Angiotensin II vs Angiotensin II alone
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports AT1 blockade for coronary vasomotor tone; leaves open clinical translation in patients.
Structured PICO
Does losartan inhibit angiotensin II-induced contraction in isolated human coronary arteries?
P
Population
Isolated human coronary artery ring segments
I
Intervention
Losartan (10-100 nM) incubated with Angiotensin II
C
Comparator
Angiotensin II alone
O
Outcome
Contractile response (pEC50 and Emax of potassium-induced contraction)surrogate
Main Result
p-value: p=0.001
This in vitro study demonstrates that angiotensin II induces vasoconstriction in human coronary arteries, which is effectively antagonized by the AT1 receptor blocker losartan.
Cite This Study
Holmgren et al. (1998) studied this question. Losartan vs. Angiotensin II alone was evaluated on Contractile effect of Angiotensin II (pEC50 and Emax) (p=0.001). Losartan antagonized Angiotensin II-induced contraction in isolated human coronary arteries, shifting the pEC50 from 9.26 to 7.00 (p=0.001) and decreasing Emax (p=0.05).