What is the clinical evidence from this study?

Population: Hypertension. Intervention: Vasodilators and NO synthase inhibition vs. Normotensive Hannover Sprague-Dawley (SD) rats. Primary outcome: Regional haemodynamic responses to vasodilators and effects of NO synthase inhibition.

May 1, 1998British Journal of PharmacologyOpen Access

The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen‐2)27) rats

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Key result

Nitric oxide-mediated vasodilator mechanisms were not impaired in hypertensive transgenic ((mRen-2)27) rats compared to normotensive rats.

Population

Conscious, hypertensive, transgenic (27) rats and normotensive, Hannover Sprague-Dawley rats

Comparison

Administration of vasodilators and NO synthase… vs Normotensive Hannover Sprague-Dawley rats…

Design

Preclinical

Authors

SGSheila M. GardinerUniversity of Nottingham JMJ E MarchUniversity of Nottingham PKP.A. KempAnalytical Engineering (United States)

Discussion

Member takes

Implication

Does not implicate NO impairment in this hypertensive rat model; leaves open beta2-adrenoceptor mechanisms for human hypertension research.

Structured PICO

Population

Conscious, hypertensive, transgenic ((mRen-2)27) rats and normotensive, Hannover Sprague-Dawley (SD) rats.

Intervention

Administration of vasodilators (acetylcholine, bradykinin, salbutamol, sodium nitroprusside) and NO synthase inhibitor (L-NAME)

Comparator

Normotensive Hannover Sprague-Dawley (SD) rats; co-infusion of angiotensin II and vasopressin to match haemodynamic effects of L-NAME

Outcome

Regional haemodynamic responses (hypotensive response, renal, hindquarters, and mesenteric vasodilatation/vasoconstriction)surrogate

There is no direct evidence for impaired NO-mediated vasodilator mechanisms in hypertensive transgenic ((mRen-2)27) rats, suggesting altered responses may involve abnormal beta2-adrenoceptor-mediated processes.

Cite This Study

Gardiner et al. (1998) studied Hypertension. Vasodilators and NO synthase inhibition vs. Normotensive Hannover Sprague-Dawley (SD) rats was evaluated on Regional haemodynamic responses to vasodilators and effects of NO synthase inhibition. Nitric oxide-mediated vasodilator mechanisms were not impaired in hypertensive transgenic ((mRen-2)27) rats compared to normotensive rats.

synapsesocial.com/papers/6a64d3bf9aeeefc9b8ef4811 https://doi.org/10.1038/sj.bjp.0701838

Topics

Hypertension management

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Implication

Does not implicate NO impairment in this hypertensive rat model; leaves open beta2-adrenoceptor mechanisms for human hypertension research.

The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen‐2)27) rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen‐2)27) rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider