Population
Male Wistar rats with one-kidney, one clip (1K1C) renal hypertension or sham operation
Comparison
0.05% captopril, 0.02% MK954, or 0.02%… vs Untreated 1K1C rats and sham-operated controls
Design
Preclinical
Follow-up
48 hours
Authors
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Does not support clinical practice change; leaves open translation of RAS-selective vascular effects from rat models to human hypertension.
Blocking the renin-angiotensin system, specifically the angiotensin II type 1 receptor, protects endothelial function in the early stages of renal hypertension in a rat model.
Hoshino et al. (1996) studied this question.
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