Why the study?
Does hypertension alter the response to endothelium-dependent and -independent vasodilators in arterioles of 1K1C rats, and is it related to vascular tone?
Population
4-week one-kidney, one clip (1K1C) hypertensive rats and normotensive control rats
Comparison
Topical application of acetylcholine… vs Normotensive control rats
Design
Preclinical
Authors
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Endothelial dysfunction in this hypertensive model appears tone-independent; hypothesis-generating for human arteriolar mechanisms.
Does hypertension alter the response to endothelium-dependent and -independent vasodilators in arterioles of 1K1C rats, and is it related to vascular tone?
Reduced endothelial-dependent vasodilation in hypertensive rats is likely due to changes in synthesis or release of endothelium-derived relaxing factor rather than differences in vascular tone.
Nakamura et al. (1992) studied this question.
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