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July 15, 1996Circulation

Effects of l -Arginine Supplementation on Endothelium-Dependent Coronary Vasodilation in Patients With Angina Pectoris and Normal Coronary Arteriograms

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Why the study?

Does intracoronary L-arginine supplementation improve endothelium-dependent coronary vasodilation in patients with microvascular angina?

Population

16 subjects

Comparison

Intracoronary infusion of L-arginine (50 mg/mm) vs Baseline response to acetylcholine without…

Design

Case-control

Authors

KEKensuke EgashiraKyushu UniversityYHYoshitaka HirookaGeneral CardiologyTKTakeshi KugaKyushu University

Discussion

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Overview

May support endothelial-targeted therapy in microvascular angina; hypothesis-generating and requires randomized confirmation.

Structured PICO

Does intracoronary L-arginine supplementation improve endothelium-dependent coronary vasodilation in patients with microvascular angina?

P
Population
16 subjects (8 patients with microvascular angina pectoris [angina pectoris and normal coronary arteriograms] and 8 control subjects)
I
Intervention
Intracoronary infusion of L-arginine (50 mg/mm)
C
Comparator
Baseline response to acetylcholine without L-arginine, and comparison between patients and control subjects
O
Outcome
Acetylcholine-induced coronary vasomotion (coronary blood flow and large epicardial coronary artery diameter)surrogate

Intracoronary L-arginine supplementation improves endothelium-dependent vasodilation of the coronary microcirculation in patients with microvascular angina.

Cite This Study

Egashira et al. (1996) studied this question.

synapsesocial.com/papers/6a855e0db605bb00f9d4c498https://doi.org/10.1161/01.cir.94.2.130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.1990 · 1,181 citations
  2. 2Coronary capillaries in patients with congestive cardiomyopathy or angina pectoris with patent main coronary arteries. Ultrastructural morphometry of endomyocardial biopsy samples.1991 · 54 citations
  3. 3Contribution of Nitric Oxide to Metabolic Coronary Vasodilation in the Human Heart1995 · 323 citations
  4. 4Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.1994 · 599 citations
  5. 5Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms1993 · 563 citations