Why the study?
Does a high-cholesterol diet alter coronary artery reactivity in pigs before the onset of atherosclerosis?
Population
Pigs (preclinical model)
Comparison
High-cholesterol diet for 9 weeks vs Normal diet
Design
Preclinical
Follow-up
9 weeks
Authors
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Early coronary endothelial dysfunction may precede atherosclerosis in hypercholesterolemia; hypothesis-generating in porcine models and leaves open human translation.
Does a high-cholesterol diet alter coronary artery reactivity in pigs before the onset of atherosclerosis?
Hypercholesterolemia induces selective endothelial cell dysfunction and abnormal coronary artery reactivity prior to the development of overt atherosclerosis.
Cohen et al. (1988) studied this question.
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