Why the study?
Does hypercholesterolemia impair endothelium-dependent relaxation and NO release in rabbit coronary resistance vessels?
Population
Langendorff hearts from rabbits fed a cholesterol-enriched diet for 4 months (n=8-9 per group)
Comparison
Cholesterol-enriched diet vs Control rabbits on standard diet
Design
Preclinical
Follow-up
4 months
Authors
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Hypothesis-generating for post-release NO defects in hypercholesterolemia; leaves open human coronary translation and therapeutic targeting.
Does hypercholesterolemia impair endothelium-dependent relaxation and NO release in rabbit coronary resistance vessels?
Hypercholesterolemia impairs endothelium-dependent relaxation in coronary resistance vessels despite increased NO generation, suggesting reduced NO action via accelerated degradation or disturbed signal transduction.
Woditsch et al. (1994) studied this question.
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