Key result
Experimental hypercholesterolemia in pigs significantly enhanced coronary vasoconstriction to ET-1 compared to normal diet (23% vs 8%, P=0.02), mediated mainly through the ETB receptor.
Population
Pigs fed either a normal or a high-cholesterol diet for 10 to 13 weeks
Comparison
Endothelin-1 and sarafotoxin 6c at cumulative… vs Pigs fed a normal diet
Design
Preclinical
Follow-up
10 to 13 weeks (diet duration)
Authors
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ETB modulation may influence coronary tone in hypercholesterolemia; leaves open human translation.
Absolute Event Rate: 23% vs 8%
p-value: p=0.02
Experimental hypercholesterolemia enhances coronary vasoconstriction to endothelins in vitro, primarily mediated through the ETB receptor.
Hasdai et al. (1997) studied Hypercholesterolemia. High-cholesterol diet vs. Normal diet was evaluated on Contraction of small coronary arteries to ET-1 at 10(-10) mol/L (p=0.02). Experimental hypercholesterolemia in pigs significantly enhanced coronary vasoconstriction to ET-1 compared to normal diet (23% vs 8%, P=0.02), mediated mainly through the ETB receptor.
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