January 1, 1994Circulation ResearchOpen Access

Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.

View Full Paper

Ask AI

Bookmark

Population

Canine coronary arteries and anesthetized open-chest dogs in a constant-pressure coronary artery perfusion…

Design

Preclinical

Authors

JTJohn R. TeerlinkHeart Failure & Transplant VBVolker BreuActelion (Switzerland)USUrs SprecherRoche (Switzerland)

Discussion

Member takes

Implication

ETB receptors mediate biphasic coronary effects in canines; extends endothelin biology but leaves open human relevance.

Structured PICO

Population

Canine coronary arteries (left circumflex) and anesthetized open-chest dogs in a constant-pressure coronary artery perfusion model

Intervention

Intracoronary sarafotoxin S6c (ETB agonist) at doses of 0.1, 0.3, 1.0, and 3.0 micrograms, with or without constant infusion of BQ-123 (ETA antagonist)

Outcome

Coronary resistance, coronary diameter, blood flow, and myocardial segmental shorteningsurrogate

ETB receptors in the canine coronary circulation mediate both vasodilation and potent vasoconstriction, highlighting their complex role in coronary vascular tone.

Cite This Study

Teerlink et al. (1994) studied this question.

synapsesocial.com/papers/6a815dee8412ed78203c3012 https://doi.org/10.1161/01.res.74.1.105

View Full Paper

Ask AI

Bookmark

Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider