Key result
Endothelin-1 administration in canine coronary arteries produced a profound reduction in coronary blood flow and myocardial ischemia, suggesting a role in the pathogenesis of coronary vasospasm.
Population
Anesthetized dogs (in vivo model) and cultured porcine aortic endothelial cells (in vitro model)
Design
Preclinical
Authors
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Supports further investigation of endothelin-1 in coronary spasm; should not yet alter patient management.
Endothelin-1 induces severe coronary vasoconstriction in vivo and its expression is upregulated by thrombogenic factors, suggesting a mechanistic role in coronary vasospasm.
Kurihara et al. (1989) studied Coronary vasospasm. Endothelin-1 (ET-1) was evaluated on Coronary blood flow and vasoconstriction. Endothelin-1 administration in canine coronary arteries produced a profound reduction in coronary blood flow and myocardial ischemia, suggesting a role in the pathogenesis of coronary vasospasm.
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