Key result
In a canine model of arterial thrombosis, endothelin-1 administration at 20 ng/kg/min significantly prolonged the time to occlusive thrombus formation compared to vehicle (105 vs 44 min, p<0.05).
Why the study?
Does endothelin-1 inhibit thrombus formation in canine models of coronary artery thrombosis?
Population
Canine models of coronary artery thrombosis
Comparison
Endothelin-1 administered as an i.v. bolus or… vs Vehicle infusion
Design
Preclinical
Authors
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Endothelin-1 may inhibit arterial thrombosis in canines; hypothesis-generating and leaves open translation to human coronary disease.
Does endothelin-1 inhibit thrombus formation in canine models of coronary artery thrombosis?
Absolute Event Rate: 105% vs 44%
p-value: p=<0.05
Endothelin-1 demonstrates antithrombotic effects in canine models of coronary artery thrombosis, suggesting a potential protective mechanism during ischemia.
Leadley et al. (1995) studied Arterial thrombosis. Endothelin-1 (ET-1) vs. Vehicle was evaluated on Time required to produce an occlusive thrombus (p=<0.05). In a canine model of arterial thrombosis, endothelin-1 administration at 20 ng/kg/min significantly prolonged the time to occlusive thrombus formation compared to vehicle (105 vs 44 min, p<0.05).
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