What question did this study set out to answer?

To investigate the relationship between intracoronary thrombus formation, pharmacological thrombolysis, and endothelin-1 release in a canine model of acute myocardial infarction.

June 1, 1993Angiology

Coronary Thrombolysis and Endothelin-1 Release

Q: What is the clinical evidence from this study?

Study design: Other. Population: Acute myocardial infarction and coronary thrombus (n=28). Intervention: Coronary thrombolysis (urokinase) vs. Nonocclusive thrombus and coronary ligation with reperfusion. Primary outcome: Endothelin-1 (ET-1) levels in aorta and coronary vein.

View Full Paper

Ask AI

Bookmark

Key result

Coronary thrombolysis with urokinase after acute MI in a canine model significantly increased endothelin-1 production in coronary vessels compared to thrombus formation alone or ligation/reperfusion.

Why the study?

Does coronary thrombolysis cause endothelin-1 release in a canine model of acute myocardial infarction?

Population

28 open-chest dogs in a canine model of acute myocardial infarction or coronary thrombus

Comparison

Coronary thrombolysis with urokinase 2 hours… vs Nonocclusive thrombus without MI and coronary…

Design

Preclinical

Follow-up

Acute (hours)

Authors

HTHaruo TomodaTokyo Institute of Technology

Discussion

Member takes

Implication

ET-1–thrombus relation in canine MI is hypothesis-generating; leaves open human relevance and therapeutic implications.

Key Points

To investigate the relationship between intracoronary thrombus formation, pharmacological thrombolysis, and endothelin-1 release in a canine model of acute myocardial infarction.
Evaluated 28 open-chest dogs divided into three experimental protocols: occlusive thrombus treated with urokinase thrombolysis two hours after acute myocardial infarction (Group I, n=15), nonocclusive thrombus without infarction (Group II, n=8), and two-hour mechanical coronary ligation followed by reperfusion (Group III, n=5).
Collected simultaneous blood samples from the aorta and the coronary vein across all groups to assess transcardiac gradients and local cardiac production of endothelin-1.
Group I exhibited significant endothelin-1 increases in both aorta and coronary vein after myocardial infarction, with significantly higher levels in the coronary vein than the aorta during urokinase thrombolysis.
Group II displayed minor increases in endothelin-1 without aortic-venous gradient differences, while Group III showed significant post-infarction endothelin-1 elevation without transcardiac gradient differences.

Structured PICO

Does coronary thrombolysis cause endothelin-1 release in a canine model of acute myocardial infarction?

Population

28 open-chest dogs divided into three groups to study endothelin-1 release during acute MI induced by coronary occlusive thrombus, nonocclusive thrombus, and coronary artery ligation.

Intervention

Coronary thrombolysis with urokinase 2 hours after MI induced by occlusive thrombus (Group I, n=15)

Comparator

Nonocclusive thrombus without MI (Group II, n=8) and coronary artery ligation for 2 hours followed by reperfusion (Group III, n=5)

Outcome

Endothelin-1 (ET-1) levels in aortic and coronary venous bloodsurrogate

Coronary thrombolysis, but not mechanical reperfusion or thrombus formation alone, induces local production of endothelin-1 in a canine model of acute MI.

Cite This Study

Haruo Tomoda (1993) studied Acute myocardial infarction and coronary thrombus (n=28). Coronary thrombolysis (urokinase) vs. Nonocclusive thrombus and coronary ligation with reperfusion was evaluated on Endothelin-1 (ET-1) levels in aorta and coronary vein. Coronary thrombolysis with urokinase after acute MI in a canine model significantly increased endothelin-1 production in coronary vessels compared to thrombus formation alone or ligation/reperfusion.

synapsesocial.com/papers/6a6f17a4439bab0cabc2ae6b https://doi.org/10.1177/000331979304400603

View Full Paper

Ask AI

Bookmark

Coronary Thrombolysis and Endothelin-1 Release

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary Thrombolysis and Endothelin-1 Release

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider