Key result
Endothelin concentration was significantly higher in coronary thrombi than in peripheral plasma (20.0 vs 0.1 fmol/ml; P<0.0001) and correlated with ST-segment resolution (r=0.523, P=0.026).
Why the study?
Does the composition of acute coronary thrombi correlate with microcirculatory dysfunction and ST-segment resolution in STEMI patients?
Population
35 consecutive STEMI patients treated with the X-Sizer thrombectomy catheter
Comparison
Thrombectomy with X-Sizer catheter and analysis… vs Peripheral plasma (for biomarker comparison)
Design
Cohort
Follow-up
1 hour post-PCI
Authors
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Endothelin-rich thrombi may contribute to impaired reperfusion in STEMI; hypothesis-generating and requires prospective validation before clinical consideration.
Observational (n=35)
Does the composition of acute coronary thrombi correlate with microcirculatory dysfunction and ST-segment resolution in STEMI patients?
Effect estimate: 280-fold enrichment (95% CI 70.0-510.0)
Absolute Event Rate: 20% vs 0.1%
p-value: p=<0.0001
Active endothelin is highly concentrated in acute coronary thrombi and correlates with microcirculatory dysfunction, suggesting a mechanism for impaired reperfusion in STEMI.
Adlbrecht et al. (2007) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=35). Coronary thrombus endothelin and leukocytes vs. Peripheral plasma was evaluated on Concentration of endothelin (ET) (280-fold enrichment, 95% CI 70.0-510.0, p=<0.0001). Endothelin concentration was significantly higher in coronary thrombi than in peripheral plasma (20.0 vs 0.1 fmol/ml; P<0.0001) and correlated with ST-segment resolution (r=0.523, P=0.026).
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