Key result
Endothelin infusion caused highly variable regional vascular effects ranging from vasodilation to pure vasoconstriction, which were poorly reflected by systemic circulatory parameters.
Population
7 anaesthetized open-chest rabbits
Design
Preclinical
Follow-up
30 minutes (three 10-min periods)
Authors
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Systemic hemodynamics may mask endothelin’s regional vascular heterogeneity; leaves open translation to human disease and targeted monitoring.
Systemic circulatory parameters poorly reflect the highly variable regional vascular activity of endothelin in an in vivo rabbit model.
Hof et al. (1989) studied this question. Endothelin was evaluated on Systemic haemodynamic changes and regional vascular effects. Endothelin infusion caused highly variable regional vascular effects ranging from vasodilation to pure vasoconstriction, which were poorly reflected by systemic circulatory parameters.
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