What question did this study set out to answer?

To investigate the effects of chronic endothelin infusion on mean arterial pressure in rats.

June 1, 1990HypertensionOpen Access

Chronic hypertension produced by infusion of endothelin in rats.

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Why the study?

Does chronic infusion of endothelin increase mean arterial pressure in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats, catheterized, housed in metabolic cages, maintained on a fixed 6 meq/day sodium…

Design

Preclinical

Follow-up

7 days

Authors

LMLuke MortensenThe University of Texas Health Science Center at San Antonio CPC M PawloskiMichigan State University NKNancy L. KanagyUniversity of New Mexico

Discussion

Member takes

Implication

Chronic ET-1 elevation sustains hypertension in rats; leaves open human translation and therapeutic targeting.

Key Points

To investigate the effects of chronic endothelin infusion on mean arterial pressure in rats.
Male Sprague-Dawley rats were catheterized and infused with endothelin-1 or endothelin-3 at varying doses over 7 days.
Daily measurements were taken for mean arterial pressure, heart rate, and other hemodynamic parameters.
Rats were maintained on a fixed sodium intake in metabolic cages during the study.
Infusion of endothelin-1 resulted in sustained increases in mean arterial pressure with dosage: 3, 5, or 7.5 pmol/kg/min increased MAP significantly (exact values not specified).
Total peripheral resistance showed minor increases that were inconsistent, while other parameters remained unaffected.
Similar results were obtained with endothelin-3, requiring higher doses for comparable effects.

Structured PICO

Does chronic infusion of endothelin increase mean arterial pressure in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats, catheterized, housed in metabolic cages, maintained on a fixed 6 meq/day sodium intake

Intervention

Infusion of endothelin-1 (ET-1) at rates of 3, 5, or 7.5 pmol/kg/min for 7 days, or endothelin-3 (ET-3)

Outcome

Mean arterial pressuresurrogate

Elevated blood levels of endothelin can produce maintained hypertension without sodium or water retention in a rat model.

Cite This Study

Mortensen et al. (1990) studied this question.

synapsesocial.com/papers/6a70d827439bab0cabc359c2 https://doi.org/10.1161/01.hyp.15.6.729

Topics

Hypertension management

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Chronic hypertension produced by infusion of endothelin in rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Chronic hypertension produced by infusion of endothelin in rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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