Why the study?
Does the C-terminal (22-38) fragment of big endothelin-1 have vasoactive effects or potentiate endothelin-1 in healthy humans?
Population
16 healthy subjects
Comparison
Intravenous infusion of the C-terminal fragment… vs 0.9% saline infusion
Design
Other
Follow-up
Acute (during and immediately after infusion)
Authors
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No vasoactive effects of (22-38) fragment in healthy humans; leaves open its role in cardiovascular disease.
Does the C-terminal (22-38) fragment of big endothelin-1 have vasoactive effects or potentiate endothelin-1 in healthy humans?
The C-terminal (22-38) fragment of big endothelin-1 does not possess independent vasoactive properties or potentiate the effects of endothelin-1 in healthy humans.
Ottosson‐Seeberger et al. (1998) studied this question.
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