April 10, 1989FEBS LettersOpen Access

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

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Population

Rat thoracic aortae (in vitro) and rats (in vivo)

Comparison

Endothelin precursors (pET-39 and hET-38) vs Endothelin (ET-21)

Design

Preclinical

Authors

TKTomoko KashiwabaraUniversity of Shizuoka YIYoshimasa InagakiKyowa Kirin (Japan)HOHideo OhtaKanazawa University

Discussion

Member takes

Implication

Endothelin precursors warrant mechanistic study in vivo; leaves open relevance to human pressor regulation before any clinical consideration.

Structured PICO

Population

Rat thoracic aortae (in vitro) and rats (in vivo)

Intervention

Endothelin precursors (pET-39 and hET-38)

Comparator

Endothelin (ET-21)

Outcome

Vasoconstrictor activity (in vitro) and pressor effect (in vivo)surrogate

Endothelin precursors have weak in vitro vasoconstrictor activity but potent in vivo pressor effects, suggesting different mechanisms of action compared to mature endothelin.

Cite This Study

Kashiwabara et al. (1989) studied this question.

synapsesocial.com/papers/6a7a55da2eb3c7e469f3f2b5 https://doi.org/10.1016/0014-5793(89)81243-8

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Implication

Endothelin precursors warrant mechanistic study in vivo; leaves open relevance to human pressor regulation before any clinical consideration.

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider