Why the study?
Do endothelin-1 and its analogs increase perfusion pressure in the rat superior mesenteric arterial bed?
Population
Perfused superior mesenteric arterial bed preparations of the rat (Krebs-Henseleit and blood-perfused)
Comparison
Endothelin-1 and analogs, with or without… vs Comparison between ET-1 and its analogs, and…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for ET-1 partial agonism in mesenteric vessels; human studies required before any clinical translation.
Do endothelin-1 and its analogs increase perfusion pressure in the rat superior mesenteric arterial bed?
ET-1 and its analogs increase perfusion pressure in the rat mesenteric bed, suggesting the presence of two receptor types and opposition by vasodilator cyclo-oxygenase products.
Hiley et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: