January 1, 2000Journal of Cardiovascular Pharmacology

Presence of Functional Endothelin-1 Receptors in Nuclear Membranes of Human Aortic Vascular Smooth Muscle Cells

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Population

Human vascular smooth muscle cells (HVSMC)

Design

Preclinical

Authors

GBGhassan BkailyUniversité de Sherbrooke SCSanaa ChoufaniHospital for Sick Children GHGhada S. HassanEnglish Institute of Sport

Discussion

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Implication

Offers no immediate clinical application; hypothesis-generating for nuclear ET-1 signaling in vascular cells.

Structured PICO

Population

Human vascular smooth muscle cells (HVSMC)

Intervention

Endothelin-1 (ET-1) applied extracellularly (superfusion) and cytosolically (perforated sarcolemma membrane technique)

Outcome

Free cytosolic ([Ca]c) and nuclear ([Ca]n) Ca2+ levels and contractionsurrogate

Functional endothelin-1 receptors are present on the nuclear membranes of human vascular smooth muscle cells and may play a role in regulating nucleoplasmic calcium levels and preventing apoptosis.

Cite This Study

Bkaily et al. (2000) studied this question.

synapsesocial.com/papers/6a83feb4a3cef8348e997f75 https://doi.org/10.1097/00005344-200036051-00121

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Presence of Functional Endothelin-1 Receptors in Nuclear Membranes of Human Aortic Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Presence of Functional Endothelin-1 Receptors in Nuclear Membranes of Human Aortic Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider