Key result
Stimulation of ET-1 receptors at the sarcolemma increased cytosolic and nuclear free Ca2+ levels, while activation of nuclear membrane ETB receptors increased intranuclear Ca2+.
Population
Human heart and vascular smooth muscle cells
Comparison
Stimulation of ET-1 receptors vs Removal of extracellular calcium
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for compartmentalized ET-1 calcium signaling in cardiomyocytes.
ET-1 receptors are present at both the sarcolemma and nuclear envelope membranes, and their activation differentially regulates cytosolic and nucleoplasmic calcium levels, potentially protecting against nuclear calcium overload.
Bkaily et al. (2003) studied this question. Endothelin-1 (ET-1) was evaluated on Transcellular calcium levels and receptor localization. Stimulation of ET-1 receptors at the sarcolemma increased cytosolic and nuclear free Ca2+ levels, while activation of nuclear membrane ETB receptors increased intranuclear Ca2+.
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