November 1, 1992Circulation Research
Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes.
Population
Cultured neonatal rat ventricular myocytes
Comparison
Endothelin-1 application vs Control condition
Design
Preclinical
Authors
Discussion
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Implication
May implicate ET-1–T-type channel signaling in hypertrophy; leaves open relevance to human disease.
Structured PICO
P
Population
Cultured neonatal rat ventricular myocytes
I
Intervention
Endothelin-1 (ET-1) application (dose-dependent, up to 10 nM)
C
Comparator
Control condition
O
Outcome
Maximum current density of T-type (ICa,T) and L-type (ICa,L) Ca2+ currents measured via patch-clamp techniquesurrogate
Endothelin-1 enhances calcium entry through sarcolemmal T-type calcium channels via a protein kinase C-dependent pathway, suggesting a mechanism for ET-1-induced cardiac hypertrophy.
Cite This Study
Furukawa et al. (1992) studied this question.