Population
Embryonic and neonatal chick ventricular myocytes, cultured neonatal rat ventricular myocytes, and adult…
Comparison
Endothelin-1 (ET-1) 10 nM exposure vs Control (unexposed)
Design
Preclinical
Authors
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ET-1 inotropy differs by species and maturity in animal myocytes; leaves open translation to human ventricular function.
Endothelin-1 produces a negative inotropic effect in immature ventricular myocytes but a positive inotropic effect in adult ventricular myocytes, indicating developmental or species-dependent responses.
Kohmoto et al. (1993) studied this question.
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