Why the study?
Does chronic endothelin-1 stimulation alter contractile function in heart tissue reconstituted from rat cardiac cells?
Population
Heart tissue reconstituted from rat cardiac cells
Comparison
Endothelin-1 (ET-1) 10 nM for 5 days vs Control / short-term ET-1 treatment for 3 hours
Design
Preclinical
Follow-up
5 days
Authors
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ET-1's dual effects on contractility may be relevant to failing myocardium; leaves open translation from rat models to human HF.
Does chronic endothelin-1 stimulation alter contractile function in heart tissue reconstituted from rat cardiac cells?
Chronic ET-1 stimulation exerts dual effects on contractility, improving basal force but impairing twitch kinetics and inotropic responsiveness, which may have adaptive and maladaptive effects in failing myocardium.
Zolk et al. (2004) studied this question.
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