Endothelin-1 and angiotensin II fail to stimulate forward Na+-H+ exchange in adult hypertrophied myocytes, suggesting a defect in the coupling of protein kinase C signaling with Na+-H+ exchange.
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Impaired ET-1 responsiveness in hypertrophied myocytes may underlie contractile deficits; hypothesis-generating for PKC-NHE uncoupling as a target in hypertrophy.
Ito et al. (1997) studied this question.
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