What does this research mean for the field?

In cardiac hypertrophy, the stimulation of Na+-H+ exchange by endothelin-1, angiotensin II, and protein kinase C is impaired, indicating a defect in the coupling of PKC signaling with the exchanger. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1997Journal of Clinical InvestigationOpen Access

Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.

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Population

Hypertrophied adult ventricular myocytes from ascending aortic banded rats and age-matched controls

Comparison

Exposure to 10 nM endothelin-1, 10 nM… vs Age-matched control myocytes

Design

Preclinical

Authors

NINobuhiko ItoKanto Central Hospital YKYutaka KagayaTohoku Bunka Gakuen University EWEllen O. WeinbergHeart Failure / Cardiomyopathy

Discussion

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Implication

Impaired ET-1 responsiveness in hypertrophied myocytes may underlie contractile deficits; hypothesis-generating for PKC-NHE uncoupling as a target in hypertrophy.

Structured PICO

Population

Hypertrophied adult ventricular myocytes from ascending aortic banded rats and age-matched controls

Intervention

Exposure to 10 nM endothelin-1 (ET-1), 10 nM angiotensin II, or phorbol ester

Comparator

Age-matched control myocytes

Outcome

Intracellular pH, intracellular [Ca2+]i, and cell contraction amplitudesurrogate

Endothelin-1 and angiotensin II fail to stimulate forward Na+-H+ exchange in adult hypertrophied myocytes, suggesting a defect in the coupling of protein kinase C signaling with Na+-H+ exchange.

Cite This Study

Ito et al. (1997) studied this question.

synapsesocial.com/papers/6a1b7f3839ea7417dc42e819 https://doi.org/10.1172/jci119123

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Implication

Impaired ET-1 responsiveness in hypertrophied myocytes may underlie contractile deficits; hypothesis-generating for PKC-NHE uncoupling as a target in hypertrophy.

Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider