Key result
Endothelin (ET-1) stimulated T- and L-type Ca2+ currents in a dose-dependent manner in human and chick ventricular single cells, an effect blocked by the ET(A) receptor antagonist BQ123 and PTX.
Population
Human and chick ventricular single cells
Design
Preclinical
Authors
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ET(A) blockade of ET-1 calcium currents warrants mechanistic follow-up; leaves open any clinical relevance pending human studies.
ET-1 stimulates T- and L-type calcium currents in ventricular cells via functional ET(A) receptors and a PTX-sensitive G-protein.
Bkaily et al. (1995) studied this question. Endothelin (ET-1) was evaluated on T- and L-type Ca2+ currents. Endothelin (ET-1) stimulated T- and L-type Ca2+ currents in a dose-dependent manner in human and chick ventricular single cells, an effect blocked by the ET(A) receptor antagonist BQ123 and PTX.
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