Key result
Endothelin-1 (10 nM) had opposite effects on the L-type Ca2+ current in human atrial myocytes, increasing low-density current by 99% and decreasing high-density current by 33%.
Why the study?
Does endothelin-1 alter the L-type Ca2+ current in human atrial myocytes?
Population
Whole cell patch-clamped human atrial myocytes
Comparison
Endothelin-1 (ET-1) 10 nM vs Baseline current amplitude
Design
Preclinical
Authors
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Baseline-dependent ET-1 effects on human atrial I_Ca suggest variable arrhythmia risk; leaves open receptor-targeted interventions.
Does endothelin-1 alter the L-type Ca2+ current in human atrial myocytes?
Endothelin-1 has dual, baseline-dependent effects on L-type Ca2+ currents in human atrial myocytes, involving both ETA and ETB receptors.
Boixel et al. (2001) studied Human atrial myocytes. Endothelin-1 (ET-1) vs. Baseline current was evaluated on L-type Ca2+ current (I(Ca)) amplitude. Endothelin-1 (10 nM) had opposite effects on the L-type Ca2+ current in human atrial myocytes, increasing low-density current by 99% and decreasing high-density current by 33%.
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