Population
Guinea-pig ventricular myocytes
Comparison
Endothelin-1 at concentrations of 1, 5, and 10 nM vs Basal conditions and isoprenaline or forskolin…
Design
Preclinical
Authors
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ET-1 may inhibit beta-adrenergic ICa,L enhancement in myocytes; leaves open relevance to human HF or arrhythmias.
Endothelin-1 potently inhibits beta-adrenergic-stimulated L-type calcium currents in ventricular myocytes via ETA receptors and PTX-sensitive G-proteins, despite having no effect on basal currents.
Thomas et al. (1997) studied this question.
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