February 1, 1992AJP Heart and Circulatory Physiology

Endothelin enhances delayed potassium current via phospholipase C in guinea pig ventricular myocytes

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Population

Single dialyzed cells from guinea pig ventricles

Design

Preclinical

Authors

YHYoshizumi HabuchiFujita Health University HTHideo TanakaKyoto Prefectural University of Medicine TFTaiji FurukawaTeikyo University Hospital

Discussion

Member takes

Implication

Hypothesis-generating for endothelin effects on ventricular IK; leaves open translation to human electrophysiology.

Structured PICO

Population

Single dialyzed cells from guinea pig ventricles

Intervention

Endothelin (big endothelin or endothelin-1)

Outcome

Delayed rectifier K+ current (IK)surrogate

Endothelin enhances the delayed rectifier K+ current in guinea pig ventricular myocytes via phospholipase C-mediated PKC activation and intracellular Ca2+ mobilization.

Cite This Study

Habuchi et al. (1992) studied this question.

synapsesocial.com/papers/6a9732cb08625d7a6989d019 https://doi.org/10.1152/ajpheart.1992.262.2.h345

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Endothelin enhances delayed potassium current via phospholipase C in guinea pig ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin enhances delayed potassium current via phospholipase C in guinea pig ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider