Population
Guinea pig atrial myocytes
Comparison
ET-1 combined with ETB-receptor-selective… vs Control (absence of ET-1 and BQ-788)
Design
Preclinical
Authors
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Extends ETA ion channel effects in guinea pig atria; leaves open relevance to human arrhythmias or inotropy.
ETA receptor stimulation augments the delayed rectifier potassium current in guinea pig atrial myocytes, which may contribute to action potential shortening and a negative inotropic response.
Kageyoshi Ono (2003) studied this question.
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