Negative Chronotropic Effect of Endothelin 1 Mediated Through ETAReceptors in Guinea Pig Atria

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Population

Guinea pig right atria

Comparison

Endothelin 1 at varying concentrations, with or… vs Control conditions or other endothelin agonists

Design

Preclinical

Authors

Discussion

ETA/pertussis toxin pathway mediates ET-1 inhibition of cAMP in cardiac tissue; leaves open translation to human disease models.

Population

Guinea pig right atria

Intervention

Endothelin 1 (ET-1) at varying concentrations (10 pmol/L to 100 nmol/L), with or without BQ123 or pertussis toxin

Comparator

Control conditions (absence of ET-1) or other endothelin agonists (ET-3, STXS6c)

Outcome

Rate of spontaneous beating (heart rate) and cAMP accumulationsurrogate

ETA receptors mediate an inhibitory cardiac action of endothelins via a pertussis toxin-sensitive G protein/adenylate cyclase inhibition pathway.

Ono et al. (1995) studied this question.

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