January 1, 1997Cardiovascular Research
Regulation of left ventricular relaxation in the isolated guinea-pig heart by endogenous endothelin
Population
Isolated ejecting guinea-pig hearts perfused with Krebs buffer at 37 degrees C, constant loading and heart…
Comparison
Specific ETA receptor antagonist BQ123, specific… vs No treatment (time controls, n=8)
Design
Preclinical
Authors
Discussion
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Implication
Guinea-pig data warrant no clinical change; hypothesis-generating for ET-1 role in diastolic function.
Structured PICO
P
Population
Isolated ejecting guinea-pig hearts perfused with Krebs buffer (1 microM indomethacin) at 37 degrees C, constant loading and heart rate (n=46)
I
Intervention
Specific ETA receptor antagonist BQ123 (1 microM), specific ETB receptor antagonist IRL 1038 (0.1 microM, 1 microM), exogenous endothelin-1 (0.01 nM, 0.1 nM), or specific ETB receptor agonist BQ3020 (5 nM)
C
Comparator
No treatment (time controls, n=8)
O
Outcome
Left ventricular performance (early left ventricular pressure decline, left ventricular end-diastolic pressure, peak left ventricular pressure, dP/dtmax, stroke volume) and coronary flowsurrogate
Basal intracardiac release of endothelin-1 significantly delays left ventricular relaxation in the isolated guinea-pig heart without affecting coronary flow.
Cite This Study
Bernard Prendergast (1997) studied this question.