Population
Guinea-pig right ventricular papillary muscles and enzymatically isolated single ventricular cells
Comparison
Endothelin vs Baseline and pretreatment with ryanodine
Design
Preclinical
Authors
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Endothelin-SR interaction in guinea-pig myocytes is hypothesis-generating; leaves open relevance to human cardiac contractility or disease.
Endothelin produces a positive inotropic effect in guinea-pig heart cells without directly activating sarcolemmal Ca2+ channels, likely by influencing sarcoplasmic reticulum function.
Tohse et al. (1990) studied this question.
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