Population
Guinea-pig cardiopulmonary tissues (in vitro) and guinea-pigs (in vivo)
Design
Preclinical
Authors
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Endothelin-1 effects in guinea-pig tissues are hypothesis-generating; human relevance and therapeutic targeting remain to be determined.
Endothelin-like immunoreactivity is present in guinea-pig cardiopulmonary tissues, and endothelin I exerts potent coronary and pulmonary vasoconstrictor effects along with concentration-dependent chronotropic and inotropic effects.
Franco‐Cereceda et al. (1990) studied this question.
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