Population
Isolated rabbit right atria and isolated dog ventricular trabeculae
Design
Preclinical
Authors
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ET-1's ETA-mediated negative chronotropic and inotropic effects may counter sympathetic drive in disease; leaves open human relevance and therapeutic translation.
Endothelin-1 exerts negative chronotropic and inotropic effects in mammalian cardiac muscle via ETA receptors, suggesting it may antagonize catecholamine-mediated cardiostimulation during pathophysiological states.
Zhu et al. (1997) studied this question.
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