Why the study?
Does endothelin-1 alter the inotropic response in dog ventricular myocardium in the presence of varying concentrations of norepinephrine?
Population
Isolated dog ventricular trabeculae
Comparison
Endothelin-1 (10 M) in the presence of various… vs ET-1 alone
Design
Preclinical
Authors
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ET-1 inotropy varies with norepinephrine levels in canine myocardium; hypothesis-generating and should not change practice.
Does endothelin-1 alter the inotropic response in dog ventricular myocardium in the presence of varying concentrations of norepinephrine?
The inotropic response to endothelin-1 in dog ventricular myocardium is highly dependent on the background concentration of norepinephrine, shifting from positive to negative as norepinephrine levels increase.
Chu et al. (2000) studied this question.
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