Population
sinoatrial (SA) node preparations of the rabbit heart
Design
Preclinical
Authors
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ET-1 inhibition of SAN currents supports negative chronotropic modulation in animals; leaves open human relevance and therapeutic implications.
Endothelin-1 exerts negative chronotropic effects on the sinoatrial node via ETA-receptors by inhibiting L-type Ca2+ and delayed rectifying K+ currents.
Tanaka et al. (1997) studied this question.
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