Population
Rabbit sinoatrial node (SAN) cells (and guinea-pig SAN cells for comparison)
Comparison
Endothelin-1 (ET-1) (10 nM or 100 nM) vs Baseline/control conditions
Design
Preclinical
Authors
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ET(A) blockade may offset ET-1 slowing of SAN pacemaking; leaves open translation to human rate control.
Endothelin-1 exerts a negative chronotropic effect on rabbit sinoatrial node cells through complex electrotonic interactions between spindle- and rod-shaped cells involving multiple ion currents.
Ono et al. (2001) studied this question.
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