Low concentrations of endothelin-1 cause long-lasting activation of a nonselective cation channel permeable to Ca2+, suggesting this channel plays an essential role in sustained intracellular Ca2+ elevation and vascular contraction.
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Highlights a Ca2+-permeable channel in ET-1 signaling; leaves open its role in human vascular disease.
Enoki et al. (1995) studied this question.
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